David Arquette & Courteney Cox Share a ‘Scream 4’ Laugh

In perhaps slightly happier times before their separation, David Arquette and Courteney Cox shared a laugh on the set of ‘Scream 4’ as fake blood-splattered Courteney wondered how best to react to a knife-wielding maniac’s attack.

“[Director Wes Craven has] done so many scary movies, and I’ll say, ‘Wes, now what do you think? How would I react if someone came up behind me with a knife, and they stabbed me?'” says Courteney. “And he’s like, ‘You know, Courteney, it’s never happened to me.'”

This comment cracks David up, and Courteney continues, “I’m just thinking, ‘Okay, well, what about the 80 movies that you’ve made? How did it go with those people?’ [Wes is] just funny, really funny.”

“It’s fun working with Courteney and David — I think they’re hilarious together,” says co-star Neve Campbell. “Their characters are sweet and wonderful and funny in a lot of ways.”

In theaters April 15, ‘Scream 4’ finds Sidney Prescott (Neve) haunted by the endless ‘Stab’ sequels being cranked out by Hollywood based on her horrendous past. Although it’s been 11 years since she was last attacked by the killer Ghostface, she’s trying to erase her reputation as a victim by becoming an acclaimed author. Of course, as soon as Sidney’s begun pulling her life back together, Ghostface has decided to make a return appearance, and it’s time for her to confront him again. Meanwhile, Gale Weathers (Courteney) has given up her job as a reporter to marry Deputy Dewey (played by David) and write a number of Stab books, but she’s got some serious writer’s block. Emma Roberts, Hayden Panettiere, Adam Brody and Anthony Anderson also star.

“Life’s dull, and then some murders happen and it just reignites everything about her, she’s excited,” says Courteney about her character. “We had such a great time making the first three [‘Scream’ movies], and I think it’s been long enough to where the people want to see what happened.”

“Coming back the first day, I was just very excited to see everyone; I was really psyched to see Courteney and David and Wes and the crew, and we’re very much like a family now,” says Neve. “Sidney, Gale, Dewey, I think they’re characters that audiences are fond of and we are fond of.”

“If you liked the other Screams, this is going to be a great one,” says David. “It’s like a return to the first.”

Watch ET for more with the stars of ‘Scream 4’!